PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo
نویسندگان
چکیده
منابع مشابه
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
Accumulating evidence suggests that PD-1, an immuno-inhibitory receptor expressed on activated T cells, regulates peripheral T cell tolerance. In particular, PD-1 is involved in the induction and/or maintenance of T cells' intrinsic unresponsiveness to previously encountered Ags, although the mechanism is yet to be determined. We used a simple experimental model to dissect the mechanism for ane...
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In this report, we show that IL-17(+)CD4(+) and IL-17(+)CD8(+) T cells are largely found in lung and digestive mucosa compartments in normal mice. Endogenous and exogenous IL-1 dramatically contribute to IL-17(+) T cell differentiation mediated by TGFbeta and IL-6. IL-1 is capable of stimulating IL-17(+) T cell differentiation in the absence of IL-6. Furthermore, although IL-2 reduces IL-17(+) ...
متن کاملIL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.
T cell responses are determined by the environment in which antigen is encountered. In the absence of proper costimulation, anergizing stimuli induce the activation of a specific program of gene expression. Proteins encoded by these genes impose a state of functional unresponsiveness in anergic T cells through the activation of different mechanisms that include dampening of the T cell receptor ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2009
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.0900080